CuralysMD™ is a topical therapeutic powered by SMRTActiv™ Technology with colloidal oatmeal, a proprietary lipid-based system designed to protect the skin barrier, calm the skin, and rebalance the microbiome. Unlike traditional moisturizers that offer temporary hydration, CuralysMD™ targets the root causes of atopic dermatitis with clinically validated mechanisms and outcomes
SMRTActiv™ is powered by two patented, plant-derived molecules with Ecocert Cosmos Natural Certification
These ingredients work synergistically to repair structural lipids, reduce pro-inflammatory signaling, and support the skin’s microbiome.
Yes. CuralysMD™ has been evaluated in two double-blind, vehicle-controlled clinical trials — one in adults and one in pediatric patients — showing significant improvements in EASI scores, itch relief, and quality of life. It also demonstrated a steroid-sparing effect and was well tolerated in both populations.
Yes. CuralysMD™ has been tested in children as young as 2 years old. The formulation was well tolerated, with no treatment-related adverse events reported in the pediatric study.
No. CuralysMD™ is non-steroidal and does not contain any corticosteroids or immunosuppressive agents. It can be used as a monotherapy or in combination with prescription topicals as part of a steroid approach.
Yes. In clinical studies, patients with active mild-to-moderate AD experienced significant improvement in both symptoms and disease severity when using CuralysMD™ twice daily.
Preclinical and clinical studies showed that CuralysMD™ helps reduce overgrowth of Staphylococcus aureus — a key driver of AD flares — while promoting the presence of beneficial flora like S. epidermidis and C. acnes.
Apply twice daily to clean, dry skin, or as directed by a healthcare provider. It may be used alongside corticosteroids, calcineurin inhibitors, or biologics.
Visit our Publications or Clinical Studies pages under The Science section for full trial summaries, data, and links to peer-reviewed journal articles.
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